Cigarette smoking is associated with Herpesviruses in persons with and without serious mental illness

Herpesviruses are recognized as major causes of human diseases. Following initial infection, Herpesviruses can undergo cycles of reactivation controlled largely by the immune system. Cigarette smoking is an important modulator of the immune system particularly in individuals with serious mental illn...

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Bibliographic Details
Published in:PloS one 2023-01, Vol.18 (1), p.e0280443-e0280443
Main Authors: Dickerson, Faith, Katsafanas, Emily, Origoni, Andrea, Newman, Theresa, Rowe, Kelly, Ziemann, Rita S, Bhatia, Kamal, Severance, Emily, Ford, Glen, Yolken, Robert
Format: Article
Language:English
Subjects:
Analysis
Antibodies
Antibodies, Viral
Biology and Life Sciences
Bipolar disorder
Cigarette Smoking
Cigarettes
Coefficients
Cohort Studies
Complications and side effects
Cytomegalovirus
Cytomegalovirus Infections
Diagnostic systems
Epstein-Barr virus
Epstein-Barr Virus Infections
Health aspects
Herpes
Herpes simplex
Herpes viruses
Herpesvirus 1, Human
Herpesvirus 3, Human
Herpesvirus 4, Human
Herpesvirus 6, Human
Herpesvirus diseases
Humans
Illnesses
Immune system
Immunoglobulin G
Infection
Medicine and health sciences
Mental disorders
Mental illness
Mentally ill
Mortality
Multiple regression models
Proteins
Regression analysis
Regression models
Risk factors
Smoking
Smoking - adverse effects
Social Sciences
Statistics
Tobacco Products
Varicella
Virions
Viruses
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Summary:Herpesviruses are recognized as major causes of human diseases. Following initial infection, Herpesviruses can undergo cycles of reactivation controlled largely by the immune system. Cigarette smoking is an important modulator of the immune system particularly in individuals with serious mental illness where smoking is associated with increased rates of cardiopulmonary diseases and mortality. However, the effect of smoking on Herpesviruses has not been extensively studied. In this nested cohort study, cigarette smoking was assessed in 1323 persons with serious mental illness or without a psychiatric disorder ascertained in a psychiatric health care system and the adjacent community. Participants provided a blood sample from which were measured IgG class antibodies to five human Herpesviruses: Cytomegalovirus (CMV), Epstein Barr Virus (EBV), Herpes Simplex Virus-Type 1 (HSV-1); Varicella Zoster Virus (VZV); and Human Herpes Virus-Type 6 (HHV-6). The associations between smoking variables and antibody levels to the Herpesviruses were analyzed among diagnostic groups in multiple regression models adjusted for age, sex, and race. Current smoking was significantly associated with higher levels of antibodies to CMV (coefficient .183, 95% CI .049, .317, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0280443