School-age outcomes among IVF-conceived children: A population-wide cohort study

In vitro fertilisation (IVF) is a common mode of conception. Understanding the long-term implications for these children is important. The aim of this study was to determine the causal effect of IVF conception on primary school-age childhood developmental and educational outcomes, compared with outc...

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Bibliographic Details
Published in:PLoS medicine 2023-01, Vol.20 (1), p.e1004148
Main Authors: Kennedy, Amber L, Vollenhoven, Beverley J, Hiscock, Richard J, Stern, Catharyn J, Walker, Susan P, Cheong, Jeanie L Y, Quach, Jon L, Hastie, Roxanne, Wilkinson, David, McBain, John, Gurrin, Lyle C, MacLachlan, Vivien, Agresta, Franca, Baohm, Susan P, Tong, Stephen, Lindquist, Anthea C
Format: Article
Language:English
Subjects:
Academic achievement
Age
Biology and Life Sciences
Child
Child development
Child, Preschool
Children
Children & youth
Cognition & reasoning
Cognitive ability
Cohort analysis
Cohort Studies
Education
Educational aspects
Epidemiology
Evaluation
Female
Fertilization in Vitro
Fertilization in vitro, Human
Humans
In vitro fertilization
Infant
Infant, Newborn
Influence
Language
Literacy
Medicine and Health Sciences
Missing data
Multiple births
People and Places
Population studies
Pregnancy
Prospective Studies
Schools
Social Sciences
Statistical analysis
Variables
Victoria - epidemiology
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Summary:In vitro fertilisation (IVF) is a common mode of conception. Understanding the long-term implications for these children is important. The aim of this study was to determine the causal effect of IVF conception on primary school-age childhood developmental and educational outcomes, compared with outcomes following spontaneous conception. Causal inference methods were used to analyse observational data in a way that emulates a target randomised clinical trial. The study cohort comprised statewide linked maternal and childhood administrative data. Participants included singleton infants conceived spontaneously or via IVF, born in Victoria, Australia between 2005 and 2014 and who had school-age developmental and educational outcomes assessed. The exposure examined was conception via IVF, with spontaneous conception the control condition. Two outcome measures were assessed. The first, childhood developmental vulnerability at school entry (age 4 to 6), was assessed using the Australian Early Developmental Census (AEDC) (n = 173,200) and defined as scoring
ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.1004148