The modifier effect of physical activity, body mass index, and age on the association of metformin and chronic back pain: A cross-sectional analysis of 21,899 participants from the UK Biobank

There is growing evidence of the anti-inflammatory effect of the anti-diabetic drug metformin and its use to reduce pain. However, we currently lack studies investigating whether metformin is associated with a reduction in chronic back pain prevalence when considering physical activity levels, body...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2023-02, Vol.18 (2), p.e0282205-e0282205
Main Authors: Carvalho-E-Silva, Ana Paula, Ferreira, Paulo H, Harmer, Alison R, Hartvigsen, Jan, Ferreira, Manuela L
Format: Article
Language:English
Subjects:
Age
Antidiabetics
Back pain
Back Pain - drug therapy
Back Pain - epidemiology
Backache
Biobanks
Biological Specimen Banks
Biology and Life Sciences
Body mass
Body Mass Index
Body size
Body weight
Care and treatment
Causes of
Comorbidity
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - epidemiology
Diagnosis
Dosage and administration
Education
Exercise
Health aspects
Humans
Inflammation
Kinases
Low Back Pain
Medicine and Health Sciences
Metformin
Metformin - therapeutic use
Obesity
Overweight
Pain
Physical activity
Physical fitness
Questionnaires
Regression analysis
Regression models
Self report
United Kingdom - epidemiology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There is growing evidence of the anti-inflammatory effect of the anti-diabetic drug metformin and its use to reduce pain. However, we currently lack studies investigating whether metformin is associated with a reduction in chronic back pain prevalence when considering physical activity levels, body mass index (BMI), and age. To investigate whether use of metformin is associated with lower levels of reporting of chronic back pain in a large cohort with type 2 diabetes when stratified for physical activity, BMI, and age. This is a cross-sectional study of 21,889 participants with type 2 diabetes who were drawn from the UK Biobank database. We investigated whether people using metformin reported a higher prevalence of chronic low back pain than those who did not. Type 2 diabetes, chronic back pain, and metformin were self-reported. Participants were stratified according to their physical activity level (low, moderate and high), BMI (normal, overweight, and obese), and age (40 to
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0282205