Exercise improves the outcome of anticancer treatment with ultrasound-hyperthermia-enhanced nanochemotherapy and autophagy inhibitor

It has been shown that exercise has a direct impact on tumor growth along with functional improvement. Previous studies have shown that exercise decreases the risk of cancer recurrence across various types of cancer. It was indicated that exercise stimulates the immune system to fight cancer. Previo...

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Bibliographic Details
Published in:PloS one 2023-07, Vol.18 (7), p.e0288380-e0288380
Main Authors: Chiang, Chi-Feng, Wang, Zi-Zong, Hsu, Yu-Hone, Miaw, Shi-Chuen, Lin, Win-Li
Format: Article
Language:English
Subjects:
Aerobics
Animals
Autophagy
Biology and Life Sciences
Blood cells
Breast cancer
Cancer
Cancer therapies
Care and treatment
Catecholamines
Chemotherapy
Chloroquine
Colorectal cancer
Combinatorial analysis
Complications and side effects
Cytokines
Doxorubicin
Exercise
Experiments
Fever
Health aspects
Health risks
Hyperthermia
Hyperthermia, Induced
Immune system
Leukocytes (neutrophilic)
Lymphocytes
Medical research
Medicine and Health Sciences
Mice
Patient outcomes
Physical fitness
Physiology
Prostate cancer
Reticulocytes
Tumors
Ultrasonic imaging
Ultrasonography
Ultrasound
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Summary:It has been shown that exercise has a direct impact on tumor growth along with functional improvement. Previous studies have shown that exercise decreases the risk of cancer recurrence across various types of cancer. It was indicated that exercise stimulates the immune system to fight cancer. Previous study demonstrated that pulsed-wave ultrasound hyperthermia (pUH) combined with PEGylated liposomal doxorubicin (PLD) and chloroquine (CQ) inhibits 4T1 tumors growth and delays their recurrence. In this study, we investigated if the combinatorial treatment with high-intensity interval training (HIIT) combined with pUH-enhanced PLD delivery and CQ improved the outcome. The mouse experiment composed of three groups, HIIT+PLD+pUH+CQ group, PLD+pUH+CQ group, and the control group. HIIT+PLD+pUH+CQ group received 6 weeks of HIIT (15 min per day, 5 days per week) before 4T1 tumor implantation. Seven days later, they received therapy with PLD (10 mg/kg) + pUH (3 MHz, 50% duty cycle, 0.65 W/cm2, 15min) + CQ (50 mg/kg daily). Results showed that HIIT+PLD+pUH+CQ significantly reduced the tumor volumes and brought about longer survival of tumor-bearing mice than PLD+pUH+CQ did. Blood cell components were analyzed and showed that neutrophil and reticulocytes decreased while lymphocytes increased after exercise.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0288380