Postoperative opioid prescribing patients with diabetes: Opportunities for personalized pain management

Opioids are commonly prescribed for postoperative pain, but may lead to prolonged use and addiction. Diabetes impairs nerve function, complicates pain management, and makes opioid prescribing particularly challenging. This retrospective observational study included a cohort of postoperative patients...

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Bibliographic Details
Published in:PloS one 2023-08, Vol.18 (8), p.e0287697
Main Authors: Zammit, Alban, Coquet, Jean, Hah, Jennifer, El Hajouji, Oualid, Asch, Steven M, Carroll, Ian, Curtin, Catherine M, Hernandez-Boussard, Tina
Format: Article
Language:English
Subjects:
Addictions
Analgesics, Opioid - adverse effects
Anesthesia
Biology and Life Sciences
Body mass index
Care and treatment
Diabetes
Diabetes mellitus
Diabetes Mellitus - drug therapy
Diabetes therapy
Diabetics
Diagnosis
Dosage and administration
Drug abuse
Electronic health records
Health risks
Hispanic people
Humans
Hypotheses
Medical diagnosis
Medical research
Medicine and Health Sciences
Medicine, Experimental
Morphine
Narcotics
Observational studies
Opiate Alkaloids
Opioid-Related Disorders
Opioids
Pain
Pain Management
Pain, Postoperative - drug therapy
Patient outcomes
Patients
Practice Patterns, Physicians
Precision medicine
Prescription writing
Prescriptions
Software
Statistical analysis
Surgery
Surgical outcomes
Variables
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Summary:Opioids are commonly prescribed for postoperative pain, but may lead to prolonged use and addiction. Diabetes impairs nerve function, complicates pain management, and makes opioid prescribing particularly challenging. This retrospective observational study included a cohort of postoperative patients from a multisite academic health system to assess the relationship between diabetes, pain, and prolonged opioid use (POU), 2008-2019. POU was defined as a new opioid prescription 3-6 months after discharge. The odds that a patient had POU was assessed using multivariate logistic regression controlling for patient factors (e.g., demographic and clinical factors, as well as prior pain and opiate use). A total of 43,654 patients were included, 12.4% with diabetes. Patients with diabetes had higher preoperative pain scores (2.1 vs 1.9, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0287697