Late-stage presentation with decompensated cirrhosis is alarmingly common but successful etiologic therapy allows for favorable clinical outcomes

• Published in: PloS one 2023-08, Vol.18 (8), p.e0290352-e0290352
• Main Authors: Schwarz, Michael, Schwarz, Caroline, Burghart, Lukas, Pfisterer, Nikolaus, Bauer, David, Hübl, Wolfgang, Mandorfer, Mattias, Gschwantler, Michael, Reiberger, Thomas
• Format: Article
• Language: English
• Subjects: Ascites; Austria; Body mass index; Care and treatment; Cholangitis; Cirrhosis; Clinical outcomes; Diabetes; Diagnosis; Endoscopy; Ethics; Etiology; Evaluation; Hepatitis; Hepatitis C; Hepatocellular carcinoma; High density lipoprotein; Hypertension; Laboratories; Liver; Liver cancer; Liver cirrhosis; Liver diseases; Medical prognosis; Medical records; Medicine and Health Sciences; Morbidity; Mortality; Patients; Serology; Statistical analysis; Stiffness; Thromboembolism; Thrombosis
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0290352

Liver cirrhosis accounts for considerable morbidity and mortality worldwide and late presentation limits therapeutic options. We aimed to assess characteristics of patients with liver cirrhosis at the time of first presentation and during their clinical course. 476 patients were included (alcohol-related liver disease, ALD: 211, 44.3%; viral hepatitis: 163, 34.2%). Of these, 106 patients (22.3%) and 160 patients (33.6%) presented already with Child-Pugh C and MELD >15, respectively, and decompensation events were registered in 50% (238 patients) at baseline, and even in 75.4% of ALD patients. Half of the patients with cirrhosis had decompensated cirrhosis at presentation. This calls for increased awareness and strategies for earlier diagnosis of chronic liver disease and cirrhosis.