Knowns and unknowns about the neurobiology of stuttering

Stuttering occurs in early childhood during a dynamic phase of brain and behavioral development. The latest studies examining children at ages close to this critical developmental period have identified early brain alterations that are most likely linked to stuttering, while spontaneous recovery app...

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Bibliographic Details
Published in:PLoS biology 2024-02, Vol.22 (2), p.e3002492
Main Authors: Neef, Nicole E, Chang, Soo-Eun
Format: Article
Language:English
Subjects:
Adult
Analysis
Biology and Life Sciences
Brain
Brain research
Case-Control Studies
Child
Child, Preschool
Children
Circuits
Computer and Information Sciences
Developmental stages
Females
Genetic aspects
Genetics
Genomes
Hierarchies
Humans
Language
Males
Medical imaging
Medicine and Health Sciences
Neural networks
Neurobiology
Neuroimaging
Neurosciences
People and Places
Social Sciences
Sound
Speech
Spontaneous recovery
Stuttering
Unsolved Mystery
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Summary:Stuttering occurs in early childhood during a dynamic phase of brain and behavioral development. The latest studies examining children at ages close to this critical developmental period have identified early brain alterations that are most likely linked to stuttering, while spontaneous recovery appears related to increased inter-area connectivity. By contrast, therapy-driven improvement in adults is associated with a functional reorganization within and beyond the speech network. The etiology of stuttering, however, remains enigmatic. This Unsolved Mystery highlights critical questions and points to neuroimaging findings that could inspire future research to uncover how genetics, interacting neural hierarchies, social context, and reward circuitry contribute to the many facets of stuttering.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3002492