Frailty and transplant-free survival of patients with liver cirrhosis: A meta-analysis

Frailty is a common condition among patients with liver cirrhosis. Nonetheless, its role in predicting liver transplant-free survival (TFS) remains unclear. This systematic review and meta-analysis were conducted to elucidate the relationship between frailty and TFS in patients with cirrhosis. Cohor...

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Bibliographic Details
Published in:PloS one 2024-05, Vol.19 (5), p.e0302836-e0302836
Main Authors: Yuan, Chunhui, Li, Weihua, Liu, Jie, Li, Jianguo
Format: Article
Language:English
Subjects:
Analysis
Asymmetry
Biology and Life Sciences
Chronic illnesses
Cirrhosis
Clinical outcomes
Cohort analysis
Confidence intervals
Frail elderly
Frailty
Frailty - complications
Health aspects
Heterogeneity
Humans
Liver
Liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - mortality
Liver diseases
Liver Transplantation
Liver transplants
Medical prognosis
Medical research
Medicine and Health Sciences
Medicine, Experimental
Meta-analysis
Mortality
Online databases
Patient outcomes
Physical Sciences
Prognosis
Research and Analysis Methods
Risk Factors
Sensitivity analysis
Statistical analysis
Subgroups
Survival
Transplantation of organs, tissues, etc
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Summary:Frailty is a common condition among patients with liver cirrhosis. Nonetheless, its role in predicting liver transplant-free survival (TFS) remains unclear. This systematic review and meta-analysis were conducted to elucidate the relationship between frailty and TFS in patients with cirrhosis. Cohort studies addressing the objective of this meta-analysis were extracted from PubMed, Embase, and Web of Science databases. Between-study heterogeneity was assessed with the Cochrane Q test, and the I^2 statistic was estimated. Random-effect models, considering potential heterogeneity, were employed to combine the results. The meta-analysis encompassed 17 cohort studies involving 6273 patients with cirrhosis, of whom 1983 (31.6%) were classified as frail at baseline. The follow-up periods in the included studies ranged from 3 to 29 months, with an average duration of 11.5 months. The analysis revealed that frailty was significantly associated with a poor TFS (risk ratio [RR]: 2.07, 95% confidence interval: 1.72 to 2.50, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0302836