Staphylococcus aureus bacteremia in alcoholics

• Published in: PloS one 2024-05, Vol.19 (5), p.e0298612
• Main Authors: Kessel, Klaus, Forsblom, Erik, Ruotsalainen, Eeva, Järvinen, Asko
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alcoholics; Alcoholism; Alcoholism - complications; Antibiotics; Archives & records; Bacteremia; Bacteremia - epidemiology; Bacteremia - microbiology; Bacterial pneumonia; Biology and Life Sciences; Blood; Blood culture; Classification; Cloxacillin; Comorbidity; Development and progression; Electronic health records; Electronic medical records; Electronic records; Endocarditis; Female; Health aspects; Hospitals; Humans; Hypotension; Illnesses; Infections; Infectious diseases; Information storage; Intensive care; Leukocytes; Liver diseases; Male; Males; Medical examination; Medical prognosis; Medical records; Medical research; Medicine and Health Sciences; Medicine, Experimental; Methicillin; Middle Aged; Mortality; Patients; Penicillin; Pneumonia; Prognosis; Radiology; Retrospective Studies; Sepsis; Social Sciences; Staphylococcal Infections - epidemiology; Staphylococcal Infections - microbiology; Staphylococcus aureus; Staphylococcus aureus - isolation & purification; Staphylococcus aureus infections
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0298612

Alcoholism associates with increased Staphylococcus aureus bacteremia incidence and mortality. The objective was to compare disease progression, treatment and prognosis of Staphylococcus aureus bacteremia in alcoholics versus non-alcoholics. The study design was a multicenter retrospective analysis of methicillin-sensitive Staphylococcus aureus bacteremia with 90-day follow-up. Patients were stratified as alcoholics or non-alcoholics based on electronic health record data. Altogether 617 Staphylococcus aureus bacteremia patients were included of which 83 (13%) were alcoholics. Alcoholics, versus non-alcoholics, were younger, typically male and more commonly had community-acquired Staphylococcus aureus bacteremia. No differences in McCabe´s classification of underlying conditions was observed. Higher illness severity at blood culture sampling, including severe sepsis (25% vs. 7%) and intensive care unit admission (39% vs. 17%), was seen in alcoholics versus non-alcoholics. Clinical management, including infectious disease specialist (IDS) consultations and radiology, were provided equally. Alcoholics, versus non-alcoholics, had more pneumonia (49% vs. 35%) and fewer cases of endocarditis (7% vs. 16%). Mortality in alcoholics versus non-alcoholics was significantly higher at 14, 28 and 90 days (14% vs. 7%, 24% vs. 11% and 31% vs. 17%), respectively. Considering all prognostic parameters, male sex (OR 0.19, p = 0.021) and formal IDS consultation (OR 0.19, p = 0.029) were independent predictors of reduced mortality, whereas ultimately or rapidly fatal comorbidity in McCabe´s classification (OR 12.34, p < 0.001) was an independent predictor of mortality in alcoholics. Alcoholism deteriorates Staphylococcus aureus bacteremia prognosis, and our results suggests that this is predominantly through illness severity at bacteremia onset. Three quarters of Staphylococcus aureus bacteremia patients we studied had identified deep infection foci, and of them alcoholics had significantly less endocarditis but nearly half of them had pneumonia.