Modular Organization of Cellular Networks

We investigated the organization of interacting proteins and protein complexes into networks of modules. A network-clustering method was developed to identify modules. This method of network-structure determination was validated by clustering known signaling-protein modules and by identifying module...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2003-02, Vol.100 (3), p.1128-1133
Main Authors: Rives, Alexander W., Galitski, Timothy
Format: Article
Language:English
Subjects:
Biological Sciences
Cell Communication
Cellular biology
Cluster Analysis
Connectivity
Databases as Topic
Datasets
Diploidy
Fungal Proteins - metabolism
Haploidy
Molecules
Protein metabolism
Signal Transduction
Signaling proteins
Software
Vertices
Yeasts
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Summary:We investigated the organization of interacting proteins and protein complexes into networks of modules. A network-clustering method was developed to identify modules. This method of network-structure determination was validated by clustering known signaling-protein modules and by identifying module rudiments in exclusively high-throughput protein-interaction data with high error frequencies and low coverage. The signaling network controlling the yeast developmental transition to a filamentous form was clustered. Abstraction of a modular network-structure model identified module-organizer proteins and module-connector proteins. The functions of these proteins suggest that they are important for module function and intermodule communication.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0237338100