Vaccine Assembly from Surface Proteins of Staphylococcus aureus

Staphylococcus aureus is the most common cause of hospitalacquired infection. Because of the emergence of antibiotic-resistant strains, these infections represent a serious public health threat. To develop a broadly protective vaccine, we tested cell wall-anchored surface proteins of S. aureus as an...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2006-11, Vol.103 (45), p.16942-16947
Main Authors: Stranger-Jones, Yukiko K., Bae, Taeok, Schneewind, Olaf
Format: Article
Language:English
Subjects:
Abscess - prevention & control
Animals
Antibodies
Antigens
Antigens, Bacterial - administration & dosage
Antigens, Bacterial - genetics
Antigens, Bacterial - immunology
Antigens, Surface - administration & dosage
Antigens, Surface - genetics
Bacterial Proteins - administration & dosage
Bacterial Proteins - genetics
Bacterial Proteins - immunology
Bacterial Vaccines - administration & dosage
Bacterial Vaccines - genetics
Biological Sciences
Calcium-Binding Proteins - administration & dosage
Calcium-Binding Proteins - genetics
Calcium-Binding Proteins - immunology
Cation Transport Proteins - administration & dosage
Cation Transport Proteins - genetics
Cation Transport Proteins - immunology
Combined vaccines
Disease prevention
Female
Humans
Immunity
Immunization
Infections
Kidneys
Membrane proteins
Membrane Proteins - administration & dosage
Membrane Proteins - genetics
Membrane Proteins - immunology
Mice
Mice, Inbred BALB C
Public health
Staphylococcal Infections - immunology
Staphylococcal Infections - prevention & control
Staphylococcus
Staphylococcus aureus
Staphylococcus aureus - genetics
Staphylococcus aureus - immunology
Staphylococcus aureus - pathogenicity
Staphylococcus infections
Vaccination
Vaccines
Vaccines, Combined - administration & dosage
Vaccines, Combined - genetics
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Description
Summary:Staphylococcus aureus is the most common cause of hospitalacquired infection. Because of the emergence of antibiotic-resistant strains, these infections represent a serious public health threat. To develop a broadly protective vaccine, we tested cell wall-anchored surface proteins of S. aureus as antigens in a murine model of abscess formation. Immunization with four antigens (IsdA, IsdB, SdrD, and SdrE) generated significant protective immunity that correlated with the induction of opsonophagocytic antibodies. When assembled into a combined vaccine, the four surface proteins afforded high levels of protection against invasive disease or lethal challenge with human clinical S. aureus isolates.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0606863103