All-DNA finite-state automata with finite memory

Biomolecular logic devices can be applied for sensing and nano-medicine. We built three DNA tweezers that are activated by the inputs H⁺/OH⁻; Hg²⁺/cysteine; nucleic acid linker/complementary antilinker to yield a 16-states finite-state automaton. The outputs of the automata are the configuration of...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2010-12, Vol.107 (51), p.21996-22001
Main Authors: Wang, Zhen-Gang, Elbaz, Johann, Remacle, F., Willner, Itamar, Levine, Raphael D.
Format: Article
Language:English
Subjects:
Automata
automaton
Biological Sciences
Chemical bases
Computers, Molecular
Cysteine - chemical synthesis
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA zymes
Fluorescence
Fluorescent Dyes - chemistry
fluorophores
Hydrogen
Hydroxides - chemistry
Life sciences
Medical technology
Memory
Mercury - chemistry
Molecular biology
Molecular logic
Nanoscience
Nucleic acids
Oligonucleotides
Physical Sciences
Protons
Rhombuses
Sciences du vivant
Sensors
Turing machines
Tweezers
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Summary:Biomolecular logic devices can be applied for sensing and nano-medicine. We built three DNA tweezers that are activated by the inputs H⁺/OH⁻; Hg²⁺/cysteine; nucleic acid linker/complementary antilinker to yield a 16-states finite-state automaton. The outputs of the automata are the configuration of the respective tweezers (opened or closed) determined by observing fluorescence from a fluorophore/quencher pair at the end of the arms of the tweezers. The system exhibits a memory because each current state and output depend not only on the source configuration but also on past states and inputs.
ISSN:0027-8424
1091-6490
1091-6490
DOI:10.1073/pnas.1015858107