Growth Inhibition and Morphological Changes Caused by Lipophilic Acids in Mammalian Cells

Human (HeLa, Chang liver, L-132, and Intestine 407) and other mammalian (XC, SV3T3, and chick-embryo) cells in tissue culture are at least as sensitive to inhibition by lipophilic acids and nitrite as bacteria. Some of these compounds are the most frequently used antimicrobial food additives. Short-...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1973-08, Vol.70 (8), p.2457-2461
Main Authors: Ginsburg, E., Salomon, D., Sreevalsan, T., Freese, E.
Format: Article
Language:English
Subjects:
Animals
Biological Sciences: Cell Biology
Butyrates
Butyrates - pharmacology
Caproates
Cell culture techniques
Cell Division - drug effects
Cell growth
Cell Line
Cell lines
Cells
Cells, Cultured - drug effects
Chick Embryo
Cultured cells
Cyclic AMP - pharmacology
Dinitrophenols - pharmacology
Epithelial cells
Fatty acids
Fatty Acids - pharmacology
Female
Food Additives - pharmacology
HeLa Cells
Humans
Intestines - embryology
Liver
Lung - embryology
Parabens - pharmacology
Propionates - pharmacology
Rats
Sarcoma, Experimental
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Summary:Human (HeLa, Chang liver, L-132, and Intestine 407) and other mammalian (XC, SV3T3, and chick-embryo) cells in tissue culture are at least as sensitive to inhibition by lipophilic acids and nitrite as bacteria. Some of these compounds are the most frequently used antimicrobial food additives. Short-chain fatty acids (up to hexanoate) and parabens induce, at partially inhibitory concentrations, a jagged cell shape in continuous epithelial-like cell lines, such as HeLa, Chang liver, L-132, and Intestine 407. This morphological effect is not mediated or enhanced by butyryl cyclic AMP, which specifically affects fibroblasts.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.70.8.2457