A Hepatic Receptor of Avian Origin Capable of Binding Specifically Modified Glycoproteins

Evidence is reported to support the following conclusions: (i) The presence of a specific hepatic receptor capable of recognizing and binding galactose-terminated glycoproteins is responsible for maintaining near zero levels of circulating asialoglycoproteins in mammalian serum. (ii) The absence of...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1976-02, Vol.73 (2), p.341-343
Main Authors: Lunney, Joan, Ashwell, Gilbert
Format: Article
Language:English
Subjects:
Acetylglucosamine - metabolism
Animals
Asialoglycoproteins
Biochemistry
Biological Evolution
Birds - metabolism
Carrier proteins
Chickens
Galactosides - metabolism
Glycoproteins
Glycoproteins - blood
Glycoproteins - metabolism
Liver
Liver - metabolism
Metabolic diseases
Physiological regulation
Rabbits
Receptors
Receptors, Drug
Structure-Activity Relationship
Turkeys
Turtles
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Evidence is reported to support the following conclusions: (i) The presence of a specific hepatic receptor capable of recognizing and binding galactose-terminated glycoproteins is responsible for maintaining near zero levels of circulating asialoglycoproteins in mammalian serum. (ii) The absence of this galactose-specific binding protein in avian, and presumably reptilian, liver is correlated with high levels of circulating asialoglycoproteins in the serum of these species. (iii) The evolutionary significance of these observations is reinforced by the recognition of an avian hepatic binding protein specific for terminal, N-acetylglucosamine residues on glycoproteins.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.73.2.341