Oxygen Chemoreception by Carotid Body Cells in Culture

Chemoreceptors for oxygen reside within the carotid body, but it is not known which cells actually sense hypoxia and by what mechanisms they transduce this information into afferent signals in the carotid sinus nerve. We have developed systems for the growth of glomus cells of the carotid body in di...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1985-03, Vol.82 (5), p.1448-1450
Main Authors: Fishman, Mark C., Greene, William L., Platika, Doros
Format: Article
Language:English
Subjects:
Adrenal Medulla - metabolism
Animals
Biological and medical sciences
Calcium
Calcium - physiology
Carotid body
Carotid Body - physiology
Cell culture techniques
Cell physiology
Cells
Cells, Cultured
Chemoreceptor Cells - physiology
Chemoreceptors
Cultured cells
Dopamine - metabolism
Epinephrine - metabolism
Fundamental and applied biological sciences. Psychology
Hypoxia
Hypoxia - physiopathology
Molecular and cellular biology
Neurons
Neurotransmission
Neurotransmitter Agents - metabolism
Norepinephrine
Oxygen
Rats
Secretion
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Summary:Chemoreceptors for oxygen reside within the carotid body, but it is not known which cells actually sense hypoxia and by what mechanisms they transduce this information into afferent signals in the carotid sinus nerve. We have developed systems for the growth of glomus cells of the carotid body in dissociated cell culture. Here we demonstrate that, as in vivo, these cells contain the putative neurotransmitters dopamine, serotonin, and norepinephrine. Oxygen tension regulates the rate of dopamine secretion from the glomus cells. Similar to chemically stimulated catecholamine secretion from other adrenergic cells this hypoxia-stimulated release requires extracellular calcium. These results are compatible with the suggestion that the glomus cells of the carotid body are chemoreceptor cells and that they signal hypoxia by regulated secretion of dopamine.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.82.5.1448