Cognate Homeo-Box Loci Mapped on Homologous Human and Mouse Chromosomes

The homeotic genes of Drosophila, which regulate pattern formation during larval development, contain a 180-base-pair DNA sequence termed the ``homeo-box.'' Nucleotide sequence comparisons indicate that the homeo-box motif is highly conserved in a variety of metazoan species. As in Drosoph...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1986-12, Vol.83 (23), p.9104-9108
Main Authors: Rabin, Mark, Ferguson-Smith, Anne, Hart, Charles P., Ruddle, Frank H.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biological Evolution
Cell lines
Chromosome Mapping
Chromosomes
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 7
DNA probes
Evolution
Fundamental and applied biological sciences. Psychology
Genes
Genes, Homeobox
Genes. Genome
Genetic loci
Human chromosomes
Humans
Mice
Molecular and cellular biology
Molecular genetics
Multigene Family
Somatic cells
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Summary:The homeotic genes of Drosophila, which regulate pattern formation during larval development, contain a 180-base-pair DNA sequence termed the ``homeo-box.'' Nucleotide sequence comparisons indicate that the homeo-box motif is highly conserved in a variety of metazoan species. As in Drosophila, homeo-box sequences of mammalian species are expressed in a temporal and tissue-specific pattern during embryogenesis. These observations suggest functional homologies between dipteran and mammalian homeo-box gene products. To identify possible relationships between homeo-box genes of mice and humans, we have compared the chromosomal location of homeo-box genes in these species. Using in situ hybridization and somatic cell genetic techniques, we have mapped the chromosome 6-specific murine Hox-1 homolog to the region p14-p21 on human chromosome 7. We have also regionally mapped the murine Hox-3 locus to 15F1-3 and its human cognate to 12q11-q21. These comparative mapping data indicate that a syntenic relationship in mice and humans is maintained for all homeo-box loci examined to date. We suggest these regions represent evolutionarily conserved genomic domains encoding homologous protein products that function in regulating patterns of mammalian development.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.83.23.9104