Conservation of the Regulatory Subunit for the Clp ATP-Dependent Protease in Prokaryotes and Eukaryotes

Bacteria, tomatoes, and trypanosomes all contain genes for a large protein with extensive homology to the regulatory subunit, ClpA, of the ATP-dependent protease of Escherichia coli, Clp. All members of the family have between 756 and 926 amino acids and contain two large regions, of 233 and 192 ami...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1990-05, Vol.87 (9), p.3513-3517
Main Authors: Gottesman, Susan, Squires, Craig, Pichersky, Eran, Carrington, Mark, Hobbs, Matthew, Mattick, John S., Dalrymple, Brian, Kuramitsu, Howard, Shiroza, Teruaki, Foster, Toshi, Clark, William P., Ross, Barbara, Squires, Catherine L., Maurizi, Michael R.
Format: Article
Language:English
Subjects:
Adenosine triphosphatases
Amino Acid Sequence
Amino acids
Analytical, structural and metabolic biochemistry
Animals
ATP-Dependent Proteases
Bacteria - enzymology
Bacteria - genetics
Bacteroides nodosus
Biological and medical sciences
Chloroplasts
DNA
Enzymes and enzyme inhibitors
Escherichia coli
Escherichia coli - enzymology
Escherichia coli - genetics
Eukaryotic cells
Fundamental and applied biological sciences. Psychology
Government regulation
Heat-Shock Proteins
Hydrolases
Introns
Molecular Sequence Data
Nucleotides
Open reading frames
Plants - enzymology
Plants - genetics
Proteins
Rhodopseudomonas blastica
Sequence Homology, Nucleic Acid
Serine Endopeptidases - genetics
Species Specificity
Streptococcus mutans - enzymology
Streptococcus mutans - genetics
Trypanosoma brucei
Trypanosoma brucei brucei - enzymology
Trypanosoma brucei brucei - genetics
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Summary:Bacteria, tomatoes, and trypanosomes all contain genes for a large protein with extensive homology to the regulatory subunit, ClpA, of the ATP-dependent protease of Escherichia coli, Clp. All members of the family have between 756 and 926 amino acids and contain two large regions, of 233 and 192 amino acids, each containing consensus sequences for nucleotide binding. Within these regions there is at least 85% similarity between the most distant members of the family. The high degree of similarity among the ClpA-like proteins suggests that Clp-like proteases are likely to be important participants in energy-dependent proteolysis in prokaryotic and eukaryotic cells.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.87.9.3513