Subplate Neuron Ablation Alters Neurotrophin Expression and Ocular Dominance Column Formation

Ocular dominance column formation in visual cortex depends on both the presence of subplate neurons and the endogenous expression of neurotrophins. Here we show that deletion of subplate neurons, which supply glutamatergic inputs to visual cortex, leads to a paradoxical increase in brain-derived neu...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1999-11, Vol.96 (23), p.13491-13495
Main Authors: Lein, E. S., Finney, E. M., McQuillen, P. S., Shatz, C. J.
Format: Article
Language:English
Subjects:
Axons
Base Sequence
Biological Sciences
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
DNA Primers
Dominance, Cerebral
Eyes
Eyes & eyesight
Gene expression
Genes
In Situ Hybridization
Injection sites
Kainic Acid - pharmacology
Messenger RNA
Neurons
Neurons - drug effects
Neurons - metabolism
Neurons - physiology
Neuroscience
Ocular dominance
RNA, Messenger - genetics
RNA, Messenger - metabolism
subplate
Visual cortex
Visual Cortex - metabolism
Visual Cortex - physiology
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Summary:Ocular dominance column formation in visual cortex depends on both the presence of subplate neurons and the endogenous expression of neurotrophins. Here we show that deletion of subplate neurons, which supply glutamatergic inputs to visual cortex, leads to a paradoxical increase in brain-derived neurotrophic factor mRNA in the same region of visual cortex in which ocular dominance columns are absent. Subplate neuron ablation also increases glutamic acid decarboxylase-67 levels, indicating an alteration in cortical inhibition. These observations imply a role for this special class of neurons in modulating activity-dependent competition by regulating levels of neurotrophins and excitability within a developing cortical circuit.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.96.23.13491