P-503: Relation of blood pressure to endothelium-dependent vasodilation in African American normotensives and hypertensives

Impaired endothelium-dependent vasodilation plays a pivotal role in the pathogenesis of hypertension and early atherosclerotic cardiovascular disease. However, the relative contribution of systolic (SBP), diastolic (DBP), mean (MBP) blood pressure and pulse pressure (PP) as determinants of endotheli...

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Bibliographic Details
Published in:American journal of hypertension 2001-04, Vol.14 (S1), p.199A-199A
Main Authors: Lapu-Bula, Rigobert, Ofili, Elizabeth, Oduwole, Adefisayo, Lankford, Brenda, Pack, Cheryl, St Vrain, Jeanette, Morgan, Jan, Nkemdiche, Sunday, Shirazi, Haider, Li, Rongling
Format: Article
Language:English
Subjects:
African Americans
Blood Pressure Indices
Endothelial function
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Summary:Impaired endothelium-dependent vasodilation plays a pivotal role in the pathogenesis of hypertension and early atherosclerotic cardiovascular disease. However, the relative contribution of systolic (SBP), diastolic (DBP), mean (MBP) blood pressure and pulse pressure (PP) as determinants of endothelial function have not been fully elucidated in population-based samples. We examined the relationship of these blood pressure indices to brachial artery endothelium-dependent vasodilation in African American hypertensives (46 ± 11 yrs) and race-matched normotensives (32 ± 12 yrs). Using high-resolution ultrasound, we measured brachial artery diameter at rest, and in response to reactive hyperemia following transient arterial occlusion (with a blood pressure cuff inflated up to 200 mmHg for 5 min). This assesses flow-mediated (FMD) or endothelium-dependent dilation, an index of endothelial function. The mean FMD was lower in hypertensives (6%, range -15 to 19%) than in normotensives (16%, range 10 to 22%) [p
ISSN:0895-7061
1941-7225
1879-1905
DOI:10.1016/S0895-7061(01)01717-4