P-124: Fibrinolytic disturbances in hypertensive subjects with microalbuminuria

• Published in: American journal of hypertension 2001-04, Vol.14 (S1), p.70A-71A
• Main Authors: Andreadis, E. A., Christopoulou- Kokkinou, V. D., Vassilopoulos, C. V., Stathopoulos, C. K., Giannakopoulos, N. S., Theodorides, T. G., Diamantopoulos, E. J.
• Format: Article
• Language: English
• Subjects: Arterial hypertension; Fibrinolysis; Microalbuminuria
• ISSN: 0895-7061; 1941-7225; 1879-1905
• DOI: 10.1016/S0895-7061(01)01674-0

The aim of the study was to investigate the possible association between disturbances of the fibrinolytic system and microalbuminuria in subjects with essential hypertension We studied 104 individuals, 51 men and 53 women, aged 56.1±7.5 years, with essential hypertension diagnosed within the last six months. They were not receiving any antihypertensive medication and they had no history of cardiovascular events. Individuals with known hypercoagulant disturbances, diabetes mellitus or impaired renal function as defined by serum creatinine levels higher than 1.3 mg/dl were excluded from the study. Office measurements of systolic and diastolic pressure were performed manually with a mercury sphygmomanometer. Urinary albumin excretion was measured by an immunoturbidimetric method (SERA-PAK immuno Microalbumin, Bayer). Subjects with urinary microalbuminuria between 30-300 mg/24hrs were considered as microalbuminuric. PAI-1 and t-PA serum concentrations were assayed with an ELISA method (STAGO). Serum levels of PAI-1 and t-PA were compared between the hypertensive subjects with and without microalbuminuria. Sixty-seven hypertensives had urine microalbumin levels