P-350: Prevention of the volume expansion induced suppression of aldosterone by rosiglitazone, in type 2 diabetic subjects

Treatment with thiazolidinediones may cause sodium retention and oedema. Peripheral vasodilation, with the secondary activation of salt and water retention, has been suggested as a possible mechanism for these effects. Head-out water immersion induces an acute volume expansion which causes a natriur...

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Bibliographic Details
Published in:American journal of hypertension 2003-05, Vol.16 (S1), p.164A-165A
Main Authors: Goenka, Nirupam, Kotonya, Christina, Penney, Michael D., O'Hare, Paul
Format: Article
Language:English
Subjects:
aldosterone
immersion
rosiglitazone
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Summary:Treatment with thiazolidinediones may cause sodium retention and oedema. Peripheral vasodilation, with the secondary activation of salt and water retention, has been suggested as a possible mechanism for these effects. Head-out water immersion induces an acute volume expansion which causes a natriuresis, rise in atrial natriuretic peptide (ANP) and suppression of aldosterone. We used this technique to study the renal and hormonal effects of rosiglitazone on type 2 diabetic subjects. The response to water immersion, for 4 hours, was compared to the response on a non-immersion control day, in 12 normal male subjects and 8 type 2 diabetic male subjects, with hourly blood and urine sampling. The experiment was repeated in the diabetic subjects after they took rosiglitazone 4mg daily for 7 days. Results given as mean±SEM. Immersion produced a natriuresis in all groups (p
ISSN:0895-7061
1941-7225
1879-1905
DOI:10.1016/S0895-7061(03)00515-6