Septal injection of botulinum neurotoxin A for idiopathic rhinitis: a pilot study

• Published in: American journal of otolaryngology 2012, Vol.33 (1), p.64-67
• Main Authors: Braun, Thomas, MD, Gürkov, Robert, MD, Kramer, Matthias F., MD, Krause, Eike, MD
• Format: Article
• Language: English
• Subjects: Anesthesia, Local; Biological and medical sciences; Botulinum Toxins, Type A - administration & dosage; Humans; Injections; Medical sciences; Nasal Septum; Neuromuscular Agents - administration & dosage; Non tumoral diseases; Otolaryngology; Otorhinolaryngology. Stomatology; Pain Measurement; Pilot Projects; Retrospective Studies; Rhinitis - drug therapy; Surgery; Treatment Outcome; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
• ISSN: 0196-0709; 1532-818X
• DOI: 10.1016/j.amjoto.2011.01.004

Abstract Purpose Botulinum neurotoxin A (BTA) is a promising therapeutic option in the treatment of idiopathic rhinitis (IR), a disease characterized by nasal obstruction and hydrous rhinorrhea. The conventional localization for the injection of BTA in IR is the nasal turbinates. In our own clinical experience, submucoperichondrial injection of BTA in the nasal septum is an alternative that is easy to perform for the therapist and also well tolerated by the patient. Material and Methods Five patients received an injection of in total 80 mouse units Dysport (Ipsen Pharma, Ettlingen, Germany) in the nasal septum. The unpleasantness of the nasal injection of BTA was measured on a visual analogue scale. Over the course of 14 days, nasal symptoms (rhinorrhea, nasal obstruction, urge to sneeze, nasal pruritus), the number of facial tissues used daily, and possible complications were evaluated. Results The unpleasantness of the injection of BTA into the nasal septum after local anesthesia was rated low (visual analogue scale, 0.76 on average). A good subjective symptom control was achieved in 3 patients concerning rhinorrhea and in all patients concerning nasal obstruction. The number of facial tissues used daily as a parameter for rhinorrhea was on average 21.0 before the injection of BTA, decreased in 4 patients over the course of time, and was on average 5.8 after 14 days. No patient reported any adverse effects after the injection of BTA. Conclusions This pilot study demonstrates that septal injection of BTA in patients with IR can achieve good symptom control and patient comfort and should be compared in further studies to the conventional turbinal injection technique.