Lineage Tracing Reveals Lgr5+Stem Cell Activity in Mouse Intestinal Adenomas

The concept that tumors are maintained by dedicated stem cells, the so-called cancer stem cell hypothesis, has attracted great interest but remains controversial. Studying mouse models, we provide direct, functional evidence for the presence of stem cell activity within primary intestinal adenomas,...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) 2012-08, Vol.337 (6095), p.730-735
Main Authors:	Schepers, Arnout G., Snippert, Hugo J., Stange, Daniel E., van den Born, Maaike, van Es, Johan H., van de Wetering, Marc, Clevers, Hans
Format:	Article
Language:	English
Subjects:	Adenoma Adenoma - genetics Adenoma - metabolism Adenoma - pathology Alleles Animal tumors. Experimental tumors Animals Architecture Biological and medical sciences Biomarkers - analysis Cancer Cell Lineage Cell Transformation, Neoplastic color Colorectal cancer Crypts Cultured cells Datasets Daughter cells Experimental digestive system and abdominal tumors G-protein coupled receptors Gene expression Gene Expression Profiling Gene Knock-In Techniques Genes Genes, Reporter Genotype & phenotype Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Neoplasms - genetics Intestinal Neoplasms - pathology Markers Medical sciences Mice Monitors Multipotent Stem Cells - pathology Multipotent Stem Cells - physiology neoplasm cells neoplasms Neoplastic Stem Cells - pathology Neoplastic Stem Cells - physiology Online Paneth Cells - pathology Receptors Receptors, G-Protein-Coupled - analysis reporter genes Rodents Stem Cell Niche Stem cells Tamoxifen - pharmacology Tumor Stem Cell Assay Tumors
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