GTPase Networks in Membrane Traffic

Members of the Rab or ARF Sar branches of the Ras GTPase superfamily regulate almost every step of intracellular membrane traffic. A rapidly growing body of evidence indicates that these GTPases do not act as lone agents but are networked to one another through a variety of mechanisms to coordinate...

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Bibliographic Details
Published in:Annual review of biochemistry 2012-01, Vol.81 (1), p.637-659
Main Authors: Mizuno-Yamasaki, Emi, Rivera-Molina, Felix, Novick, Peter
Format: Article
Language:English
Subjects:
ADP-Ribosylation Factors - metabolism
Animals
ARF
Biochemistry
Cells
effector
Endosomes - metabolism
Golgi Apparatus - metabolism
GTP Phosphohydrolases - metabolism
GTPase-activating protein
guanine nucleotide exchange factor
Humans
Membranes
Metabolic Networks and Pathways
Protein Transport
Proteins
Rab
rab GTP-Binding Proteins - metabolism
Signal transduction
vesicular transport
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Description
Summary:Members of the Rab or ARF Sar branches of the Ras GTPase superfamily regulate almost every step of intracellular membrane traffic. A rapidly growing body of evidence indicates that these GTPases do not act as lone agents but are networked to one another through a variety of mechanisms to coordinate the individual events of one stage of transport and to link together the different stages of an entire transport pathway. These mechanisms include guanine nucleotide exchange factor (GEF) cascades, GTPase-activating protein (GAP) cascades, effectors that bind to multiple GTPases, and positive-feedback loops generated by exchange factor-effector interactions. Together these mechanisms can lead to an ordered series of transitions from one GTPase to the next. As each GTPase recruits a unique set of effectors, these transitions help to define changes in the functionality of the membrane compartments with which they are associated.
ISSN:0066-4154
1545-4509
DOI:10.1146/annurev-biochem-052810-093700