Clinical features of eleven cases of Mycobacterium avium-intracellulare complex pulmonary disease associated with pneumoconiosis

The relationship between silicosis and tuberculosis is well known. Also other mycobacteria such as Mycobacterium kansasii often occur in association with pneumoconiosis. However, there are few reports describing an association of M. avium-intracellulare complex (MAC) lung disease and pneumoconiosis....

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Bibliographic Details
Published in:Respiratory medicine 2004-08, Vol.98 (8), p.721-725
Main Authors: Fujita, Jiro, Kishimoto, Takumi, Ohtsuki, Yuji, Shigeto, Eriko, Ohnishi, Takayuki, Shiode, Masahiro, Yamaji, Yasufumi, Suemitsu, Ichizo, Yamadori, Ichiro, Bandoh, Shuji, Nishimura, Kazutaka, Matsushima, Toshiharu, Ishida, Toshihiko
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Humans
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
Male
Medical sciences
Middle Aged
Mycobacterium avium intracellulare complex (MAC) infection
Mycobacterium avium-intracellulare Infection - complications
Mycobacterium avium-intracellulare Infection - diagnostic imaging
Pneumoconiosis
Pneumoconiosis - complications
Pneumology
Retrospective Studies
Silicosis
Tomography, X-Ray Computed - methods
Toxicology
Welders’ pneumoconiosis
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Summary:The relationship between silicosis and tuberculosis is well known. Also other mycobacteria such as Mycobacterium kansasii often occur in association with pneumoconiosis. However, there are few reports describing an association of M. avium-intracellulare complex (MAC) lung disease and pneumoconiosis. The purpose of the present study is to describe clinical features of MAC respiratory infection associated with pneumoconiosis. Eleven patients with MAC respiratory infection associated with pneumoconiosis (all men, 6 with silicosis and 5 with welders’ pneumoconiosis) were collected. A determination of whether or not MAC caused pulmonary disease was made using the 1997 criteria required by the American Thoracic Society. Radiologically, cavity formation as well as upper lung field predominance of MAC disease were observed in 8 of 11 cases (72.7%). Two of 11 patients died of respiratory failure. Our present study clearly demonstrates that clinical features of MAC respiratory infection associated with pneumoconiosis were different from MAC without underlying diseases.
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2004.02.011