An infant with aortoiliac thrombosis due to congenital protein C deficiency: anesthetic implications

Activated protein C (aPC) exerts its anticoagulant activity primarily through inactivation of coagulation Factors Va and VIIIa, which are required for Factor X activation and thrombin generation. The catalytic activity of aPC is greatly enhanced by the vitamin K-dependent cofactor protein S. The mos...

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Bibliographic Details
Published in:Journal of clinical anesthesia 2012-09, Vol.24 (6), p.506-507
Main Authors: Kumar, Narendra, MD, Dogra, Neelam, MD
Format: Article
Language:English
Subjects:
Anesthesia & Perioperative Care
Anesthesia - methods
Anesthetics - administration & dosage
Anticoagulants
Aorta, Abdominal
Coronary vessels
Dopamine
Drug therapy
Female
Humans
Iliac Artery
Infant
Mortality
Pain management
Pain Medicine
Postoperative period
Protein C Deficiency - complications
Protein C Deficiency - congenital
Proteins
Thrombosis - etiology
Thrombosis - physiopathology
Veins & arteries
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Description
Summary:Activated protein C (aPC) exerts its anticoagulant activity primarily through inactivation of coagulation Factors Va and VIIIa, which are required for Factor X activation and thrombin generation. The catalytic activity of aPC is greatly enhanced by the vitamin K-dependent cofactor protein S. The most common sites of thrombosis are the deep veins of the lower extremities, although an elevated risk of mesenteric vein and cerebral sinus thrombosis is also well documented [1-3].
ISSN:0952-8180
1873-4529
DOI:10.1016/j.jclinane.2011.08.009