Cullins and cell cycle control

Cullins are a recently identified protein family whose founder member, CUL-1, controls cell proliferation inCaenorhabditis elegans and which is conserved from yeasts to humans. Cullins have been found to be subunits of three different protein complexes: the Skpl-cullin-F-box complex (SCF), the anaph...

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Bibliographic Details
Published in:Protoplasma 2000-01, Vol.211 (1-2), p.20-28
Main Authors: Gieffers, C, Schleiffer, A, Peters, J. -M
Format: Article
Language:English
Subjects:
Cell cycle
cell proliferation
humans
Proteins
proteolysis
regulatory proteins
tumor suppressor proteins
ubiquitin
yeasts
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Summary:Cullins are a recently identified protein family whose founder member, CUL-1, controls cell proliferation inCaenorhabditis elegans and which is conserved from yeasts to humans. Cullins have been found to be subunits of three different protein complexes: the Skpl-cullin-F-box complex (SCF), the anaphase-promoting complex (APC), and the CUL-2 elongin B/C-pVHL complex (CBCⱽᴴᴸ). The SCF and the APC control progression through the cell cycle by mediating ubiquitin-dependent proteolysis of regulatory proteins. The CBCⱽᴴᴸ complex has been identified through characterization of one of its subunits, the von Hippel-Lindau tumor suppressor protein (pVHL). The function of CBCⱽᴴᴸ is unknown, but recent observations raise the possibility that also this complex is a component of the ubiquitin system.
ISSN:0033-183X
1615-6102
DOI:10.1007/BF01279896