Gastrointestinal cancer

A combination of both environmental and genetic factors contributes to the vast majority of human cancers and in particular cancers of the gastrointestinal tract, including the stomach, colon and rectum. The mechanisms associated with cancer causation or prevention are largely unknown and the subjec...

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Bibliographic Details
Published in:Baillière's best practice & research. Clinical gastroenterology 2004-04, Vol.18 (2), p.323-336
Main Authors: Heavey, Patricia M, Rowland, Ian R
Format: Article
Language:English
Subjects:
Colon
Colorectal cancer
DNA methylation
gastrointestinal cancer
Helicobacter pylori
Infections
microflora
Ulcers
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Summary:A combination of both environmental and genetic factors contributes to the vast majority of human cancers and in particular cancers of the gastrointestinal tract, including the stomach, colon and rectum. The mechanisms associated with cancer causation or prevention are largely unknown and the subject of much research. Many of these mechanisms implicate the metabolic activities of the bacterial flora normally resident in the gastrointestinal tract. This paper examines both the detrimental and beneficial consequences of bacterial activity of the gastrointestinal tract, focusing in particular on the stomach and large intestine.
ISSN:1521-6918
1532-1916
DOI:10.1016/j.bpg.2003.10.003