Enantioselective Synthesis of Terminal 1,2-Diols from Acyl Chlorides

Optically active terminal 1,2-diols were prepared with high enantiopurity via the TMS-quinidine-catalyzed en- antioselective cyclization of acyl chlorides and oxaziridine, followed by reductive ring-opening of the cycloadducts.

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Bibliographic Details
Published in:Chinese journal of chemistry 2012-11, Vol.30 (11), p.2688-2692
Main Author: 邵攀霖 申理滔 叶松
Format: Article
Language:English
Subjects:
1,2‐diols
2-diols
acyl chlorides
cinchona alkaloids
enantioselective synthesis
oxidation
不对称合成
二醇
光学活性
对映体纯度
氮杂环丙烷
烯酮类化合物
终端
酰氯
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Description
Summary:Optically active terminal 1,2-diols were prepared with high enantiopurity via the TMS-quinidine-catalyzed en- antioselective cyclization of acyl chlorides and oxaziridine, followed by reductive ring-opening of the cycloadducts.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201200697