iPSC Disease Modeling

Induced pluripotent stem cell technology has great potential to model human diseases, but faces many challenges. Induced pluripotent stem cell (iPSC) technology has provided previously unanticipated possibilities to model human disease in the culture dish. Reprogramming somatic cells from patients i...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2012-11, Vol.338 (6111), p.1155-1156
Main Authors: Soldner, Frank, Jaenisch, Rudolf
Format: Article
Language:English
Subjects:
Biomedical technology
Cell lines
Cells
Disease
Disease models
Emerging diseases
Genetic disorders
Human genetics
Medical genetics
Medical research
PERSPECTIVES
Phenotypes
Pluripotent stem cells
Stem cells
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Summary:Induced pluripotent stem cell technology has great potential to model human diseases, but faces many challenges. Induced pluripotent stem cell (iPSC) technology has provided previously unanticipated possibilities to model human disease in the culture dish. Reprogramming somatic cells from patients into an embryonic stem cell–like state ( 1 ) followed by differentiation into disease-relevant cell types can generate an unlimited source of human tissue carrying the genetic variations that caused or facilitated disease development ( 2 ). Yet, despite the excitement over this “disease-in-a-dish” approach, studying genetic disorders in patient-derived cells faces more challenges than studies using genetically well-defined model systems. Here we describe some of these limitations, and also present some solutions for ensuring that iPSC technology lives up to at least some of its promise.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1227682