Prevalence of cervical human papillomavirus infection in women with systemic lupus erythematosus

Genital infection by human papillomavirus (HPV) tends to occur more frequently in patients with conditions associated with immune suppression. Systemic lupus erythematosus (SLE) is an immunological disorder characterized by generalized inflammation and a number of clinical manifestations and circula...

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Bibliographic Details
Published in:Rheumatology international 2013-02, Vol.33 (2), p.335-340
Main Authors: Lyrio, Leomar D. C., Grassi, Maria Fernanda R., Santana, Iuri U., Olavarria, Viviana G., Gomes, Aline do N., CostaPinto, Licia, Oliveira, Rone Peterson C., Aquino, Rita de Cássia R., Santiago, Mittermayer B.
Format: Article
Language:English
Subjects:
Adult
Cross-Sectional Studies
Female
Humans
Immunosuppressive Agents - adverse effects
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diet therapy
Medicine
Medicine & Public Health
Middle Aged
Original Article
Papillomavirus Infections - epidemiology
Papillomavirus Infections - etiology
Prevalence
Rheumatology
Uterine Cervical Diseases - epidemiology
Uterine Cervical Diseases - etiology
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Summary:Genital infection by human papillomavirus (HPV) tends to occur more frequently in patients with conditions associated with immune suppression. Systemic lupus erythematosus (SLE) is an immunological disorder characterized by generalized inflammation and a number of clinical manifestations and circulating autoantibodies. The aim of the present study was to determine the prevalence of genital HPV infection among female SLE patients. Women diagnosed with SLE based on American College of Rheumatology classification criteria followed at rheumatology outpatient clinic of the Escola Bahiana de Medicina e Saude Publica, Salvador, Brazil, were included in the study. As a comparison group, clinically healthy women who were attending the gynecology outpatient clinic for routine examination at the same institution were recruited. Testing for cervical HPV infection was performed using the nested polymerase chain reaction technique. Eighty-eight female SLE patients (mean age, 41.4 ± 11.6 years) and seventy healthy female subjects (control group) were studied. The prevalence of HPV infection was 80.7 % (71/88) in the SLE group and 35.7 % (25/70) in the control group ( p  
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-012-2426-0