A neural systems theory of schizophrenia and tardive dyskinesia

• Published in: Behavioral Science 1976-07, Vol.21 (4), p.274-288
• Main Author: Glassman, Robert B.
• Format: Article
• Language: English
• Subjects: Corpus Striatum - drug effects; Corpus Striatum - physiopathology; Dyskinesia, Drug-Induced - etiology; Dyskinesia, Drug-Induced - physiopathology; Frontal Lobe - physiopathology; Humans; neuroleptics; Regression (Psychology); schizophrenia; Schizophrenia - drug therapy; Schizophrenia - etiology; Schizophrenia - physiopathology; Schizophrenic Psychology; systems; tardive dyskinesia; Tranquilizing Agents - pharmacology; Tranquilizing Agents - therapeutic use
• ISSN: 0005-7940; 1099-1743; 1932-300X
• DOI: 10.1002/bs.3830210408

Some systems ideas applied to individual persons are used to try to explain symptoms of schizophrenia and a syndrome of uncontrolled fragments of movement which sometimes occurs as a side effect of chronic, antipsychotic drug therapy. The behavior of normal organisms may be conceptualized in three echelons of control, with each successively higher echelon organizing, by selective disinhibition, semiautonomous, spontaneous fragments of activity which comprise the next lower echelon. It is hypothesized that schizophrenia involves a deficiency of inhibition by the frontal cortex, first echelon, on the corpus striatum, second echelon. This results first in insufficiently integrated fragments of behavior, and second in premature associative linkages among active elements. First echelon control develops as a normal person matures and gradually loses some of the playful activities of childhood. It is hypothesized that by disrupting certain aspects of activity in the corpus striatum, neuroleptic drugs reduce schizophrenic symptoms but also reduce the capacity of the second echelon to inhibit and integrate the smaller behavioral fragments wired into lower parts of the brain, third echelon. This results in uncontrolled movements. Though many researchers already favor the hypothesis that neuroleptic drugs act on the corpus striatum, the broader theory presented here is new and depends in large part on general living systems considerations. Emphasis is on conceptual decomposition of the integrated behavior of a whole organism into less complex subsystems. Individually, these have neither too much nor too little complexity to yield a plausible model. Some experimental predictions and predictions about possible therapies are made from the theory.