The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice

Sexual dimorphism in body weight, fat distribution, and metabolic disease has been attributed largely to differential effects of male and female gonadal hormones. Here, we report that the number of X chromosomes within cells also contributes to these sex differences. We employed a unique mouse model...

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Bibliographic Details
Published in:PLoS genetics 2012-05, Vol.8 (5), p.e1002709
Main Authors: Chen, Xuqi, McClusky, Rebecca, Chen, Jenny, Beaven, Simon W., Tontonoz, Peter, Arnold, Arthur P., Reue, Karen
Format: Article
Language:English
Subjects:
Adiposity - genetics
Adiposity - physiology
Animals
Biology
Chromosomes
Complications and side effects
Diabetes
Diet, High-Fat
Dimorphism (Biology)
Female
Gene mutations
Genetic aspects
Gonadal Hormones - metabolism
Gonads - cytology
Gonads - metabolism
Insulin - blood
Lipid Metabolism - genetics
Lipids - blood
Male
Medicine
Metabolic disorders
Metabolism
Mice
Obesity
Obesity - genetics
Physiological aspects
Sex Characteristics
Sex Determination Processes
Weight Gain - genetics
Womens health
X chromosome
X Chromosome - genetics
X Chromosome - physiology
Y Chromosome - genetics
Y Chromosome - physiology
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