Maternal serum 25-hydroxyvitamin D and placental vascular pathology in a multicenter US cohort

Background: Maternal vitamin D deficiency has been linked to fetal growth restriction, but the underlying mechanisms are unclear.Objective: We tested the hypothesis that poor maternal 25-hydroxyvitamin D [25(OH)D] is associated with increased risk of placental vascular pathology.Design: Maternal ser...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2013-08, Vol.98 (2), p.383-388
Main Authors: Gernand, Alison D, Bodnar, Lisa M, Klebanoff, Mark A, Parks, W Tony, Simhan, Hyagriv N
Format: Article
Language:English
Subjects:
Adult
Babies
Biological and medical sciences
birth weight
Birth Weight - drug effects
blood serum
boys
clinical nutrition
Cohort Studies
Diseases of mother, fetus and pregnancy
Feeding. Feeding behavior
Female
fetal development
Fetal Growth Retardation - blood
Fetal Growth Retardation - etiology
Fetal Growth Retardation - physiopathology
fetus
Fundamental and applied biological sciences. Psychology
Gynecology. Andrology. Obstetrics
Humans
hypoxia
Infant
infants
infarction
Logistic Models
Male
Maternal Nutritional Physiological Phenomena
Medical sciences
Mothers
Nutritional Status
Perinatal Care
Placenta - blood supply
Placenta - pathology
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - physiopathology
Pregnancy. Fetus. Placenta
progeny
risk
Risk assessment
thrombosis
United States
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin D
Vitamin D - blood
vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - physiopathology
Vitamin deficiency
vitamin status
Young Adult
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Summary:Background: Maternal vitamin D deficiency has been linked to fetal growth restriction, but the underlying mechanisms are unclear.Objective: We tested the hypothesis that poor maternal 25-hydroxyvitamin D [25(OH)D] is associated with increased risk of placental vascular pathology.Design: Maternal serum 25(OH)D was measured at ≤26 wk of gestation in a random subcohort of term, singleton infants in the Collaborative Perinatal Project (1959–1966; n = 2048). A dichotomous vascular construct was created from the presence of any of 12 pathologies identified on placental examinations, including evidence of placental abruption, infarction, hypoxia, decidual vasculopathy, or thrombosis of fetal vessels (n = 240 cases).Results: The relation between 25(OH)D and vascular pathology was modified by infant sex (P = 0.003). A maternal 25(OH)D concentration ≥80 compared with
ISSN:0002-9165
1938-3207
DOI:10.3945/ajcn.112.055426