Metabolism of Ginsenoside Rc by Human Intestinal Bacteria and Its Related Antiallergic Activity

When ginsenoside Rc was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside Rc to compound K and protopanaxadiol. The main metabolite was compound K. Among the bacteria isolated from human fecal microflora, most bacteria, such as Bacteroides sp., Eubacterium sp...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2002, Vol.25(6), pp.743-747
Main Authors: Bae, Eun-Ah, Choo, Min-Kyung, Park, Eun-Kyung, Park, Sun-Young, Shin, Ho-Young, Kim, Dong-Hyun
Format: Article
Language:English
Subjects:
antiallergy
Biological and medical sciences
compound K
General pharmacology
ginsenoside Mb
ginsenoside Rc
intestinal bacteria
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
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Summary:When ginsenoside Rc was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside Rc to compound K and protopanaxadiol. The main metabolite was compound K. Among the bacteria isolated from human fecal microflora, most bacteria, such as Bacteroides sp., Eubacterium sp., and Bifidobacterium sp. potently transformed ginsenoside Rc to compound K. Bifidobacterium K-103 and Eubacterium A-44 transformed it to compound K via ginsenoside Rd, and Bacteroides HJ-15 and Bifidobacterium K-506 metabolized to compound K via ginsenoside Mb, which was isolated as a new metabolite (M.W. 940[+Na]). Among ginsenoside Rc and its metabolites, compound K exhibited the most potent antiallergic activity on the IgE-induced RBL cell line as well as potent cytotoxic activity against tumor cell lines.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.25.743