Synthesis of Biologically Active Carbazole Alkaloids Using Selective Transition-metal-catalyzed Coupling Reactions

Highly convergent syntheses of substituted carbazoles are most conveniently achieved using organometallic chemistry. Construction of the carbazole framework via the iron-mediated route proceeds by a sequence of C–C and C–N bond formation. In the highly efficient palladium-catalyzed route the C–N bon...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry letters 2009, Vol.38 (1), p.8-13
Main Author: Knölker, Hans-Joachim
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highly convergent syntheses of substituted carbazoles are most conveniently achieved using organometallic chemistry. Construction of the carbazole framework via the iron-mediated route proceeds by a sequence of C–C and C–N bond formation. In the highly efficient palladium-catalyzed route the C–N bond is formed first followed by generation of the C–C bond. This article highlights some recent developments and applications to the total synthesis of biologically active carbazole alkaloids.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2009.8