Chloral hydrate sedation for magnetic resonance imaging in newborn infants

Summary Background The aim of this study was to look for clinically significant adverse effects of chloral hydrate used in a large cohort of infants sedated for magnetic resonance imaging. Method Case notes of infants who underwent magnetic resonance imaging (MRI) scanning from 2008 to 2010 were rev...

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Bibliographic Details
Published in:Pediatric anesthesia 2014-02, Vol.24 (2), p.190-195
Main Authors: Finnemore, Anna, Toulmin, Hilary, Merchant, Naz, Arichi, Tom, Tusor, Nora, Cox, David, Ederies, Ash, Nongena, Phumza, Ko, Christopher, Dias, Ryan, Edwards, Anthony D., Groves, Alan M.
Format: Article
Language:English
Subjects:
adverse effects
Birth Weight
chloral hydrate
Chloral Hydrate - administration & dosage
Chloral Hydrate - adverse effects
Conscious Sedation - methods
Gestational Age
Humans
Hypnotics and Sedatives - administration & dosage
Hypnotics and Sedatives - adverse effects
infant
Infant, Newborn
Infant, Premature
magnetic resonance imaging
Magnetic Resonance Imaging - methods
newborn
Oxygen - blood
patient monitoring
patient safety
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Summary:Summary Background The aim of this study was to look for clinically significant adverse effects of chloral hydrate used in a large cohort of infants sedated for magnetic resonance imaging. Method Case notes of infants who underwent magnetic resonance imaging (MRI) scanning from 2008 to 2010 were reviewed, with patient demographics, sedation dose, comorbidities, time to discharge, and side effects of sedation noted. Results Four hundred and eleven infants (median [range] postmenstrual age per weight at scan 42 [31+4–60] weeks per 3500 g [1060–9900 g]) were sedated with chloral hydrate (median [range] dose 50 [20–80] mg·kg−1). In three cases (0.7%), desaturations occurred which prompted termination of the scan. One infant (0.2%) was admitted for additional observation following sedation but had no prolonged effects. In 17 (3.1%) cases, infants had desaturations which were self‐limiting or responded to additional inspired oxygen such that scanning was allowed to continue. Conclusion When adhering to strict protocols, MRI scanning in newborn infants in this cohort was performed using chloral hydrate sedation with a relatively low risk of significant adverse effects.
ISSN:1155-5645
1460-9592
DOI:10.1111/pan.12264