Is leptin a key mediator in the link between immune responses and metabolism in autoimmune diseases of the central nervous system?

The non‐glycosylated protein, leptin, plays a key role in regulating energy intake and energy expenditure. It was also recently shown to be involved in regulating innate and adaptive immune responses. Ehsan et al. reported significantly higher serum leptin levels in patients with multiple sclerosis...

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Bibliographic Details
Published in:Clinical & experimental neuroimmunology 2014-02, Vol.5 (1), p.4-5
Main Author: Niino, Masaaki
Format: Article
Language:English
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Summary:The non‐glycosylated protein, leptin, plays a key role in regulating energy intake and energy expenditure. It was also recently shown to be involved in regulating innate and adaptive immune responses. Ehsan et al. reported significantly higher serum leptin levels in patients with multiple sclerosis and neuromyelitis optica, and these levels were correlated with disability in those with progressive multiple sclerosis. Leptin's role as a mediator in the link between the immune responses and metabolic function is clearly important to consider in developing immune therapeutic targets for reducing inflammation and autoimmunity.
ISSN:1759-1961
1759-1961
DOI:10.1111/cen3.12095