Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis

To the Editor: The role of bacterial colonization or infection in chronic rhinosinusitis (CRS) is unclear and has not been thoroughly investigated in CRS with nasal polyps (NPs), a subgroup of patients with often severe eosinophilic inflammation, a high recurrence rate, and frequent asthma comorbidi...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2004-10, Vol.114 (4), p.981-983
Main Authors: Van Zele, Thibaut, Gevaert, Philippe, Watelet, Jean-Baptiste, Claeys, Geert, Holtappels, Gabriele, Claeys, Cindy, van Cauwenberge, Paul, Bachert, Claus
Format: Article
Language:English
Subjects:
Adult
Allergies
Aspirin
Aspirin - adverse effects
Aspirin - immunology
Asthma - complications
Asthma - immunology
Chronic Disease
Comorbidity
Drug Hypersensitivity - complications
Drug Hypersensitivity - immunology
Enterotoxins - immunology
Female
Humans
Immunoglobulin E - immunology
Male
Middle Aged
Nasal Polyps - complications
Nasal Polyps - immunology
Patients
Rhinitis - complications
Rhinitis - immunology
Sinusitis - complications
Sinusitis - immunology
Staphylococcal Infections - immunology
Staphylococcus aureus - immunology
Studies
Citations: Items that cite this one
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Summary:To the Editor: The role of bacterial colonization or infection in chronic rhinosinusitis (CRS) is unclear and has not been thoroughly investigated in CRS with nasal polyps (NPs), a subgroup of patients with often severe eosinophilic inflammation, a high recurrence rate, and frequent asthma comorbidity and aspirin sensitivity.1 In the whole group of patients with CRS, a Staphylococcus aureus carriage rate of 35% was observed at the middle meatus.2S aureus also frequently colonizes the nostrils in healthy subjects and may form enterotoxins, which under appropriate conditions can penetrate the mucosal barrier and possibly act as superantigens on T and B lymphocytes. [...]the presence of a local immune response to superantigens, characterized by IgE formation to SAEs, is strongly associated with asthma in patients with NP.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2004.07.013