Mobilizing cells to the injured myocardium: A novel rescue strategy or an unwelcome intrusion?Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology

Mobilizing endogenous stem cells is an attractive strategy because it obviates the use of exogenous cells and avoids ethical and immunity issues, and granulocyte-macrophage colony-stimulating factor (GM-CSF) and GCSF are used clinically (e.g., in patients with immunosuppression, after bone marrow tr...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2004-10, Vol.44 (7), p.1521
Main Author: Lew, Wilbur YW
Format: Article
Language:English
Subjects:
Bone marrow
Cardiology
Heart attacks
Mortality
Stem cells
Studies
Online Access:Get full text
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Summary:Mobilizing endogenous stem cells is an attractive strategy because it obviates the use of exogenous cells and avoids ethical and immunity issues, and granulocyte-macrophage colony-stimulating factor (GM-CSF) and GCSF are used clinically (e.g., in patients with immunosuppression, after bone marrow transplantation, or to mobilize progenitor cells into peripheral blood for harvesting). The optimal timing for stem cell therapy requires understanding the homing signals from damaged tissue, the fate of transplanted cells (e.g., ability and/or requirement for stem cells to engraft and transdifferentiate into specific cell types), and the mechanisms of beneficial effects (e.g., angiogenesis, replacing damaged tissue to improve scaffolding, facilitation of normal repair processes).
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2004.07.005