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Gender-Specific Risk Stratification With B-Type Natriuretic Peptide Levels in Patients With AcuteDyspnea: Insights From the B-type Natriuretic Peptide for Acute Shortness of Breath Evaluation Study

Gender-Specific Risk Stratification With B-Type Natriuretic Peptide Levels in Patients With Acute Dyspnea: Insights From the B-type Natriuretic Peptide for Acute Shortness of Breath Evaluation Study Michael Christ, Kirsten Laule-Kilian, Willibald Hochholzer, Theresia Klima, Tobias Breidthardt, Andre...

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Published in:Journal of the American College of Cardiology 2006-11, Vol.48 (9), p.1808
Main Authors: Christ, Michael, Laule-Kilian, Kirsten, Hochholzer, Willibald, Klima, Theresia, Breidthardt, Tobias, Perruchoud, Andre P, Mueller, Christian
Format: Article
Language:English
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Summary:Gender-Specific Risk Stratification With B-Type Natriuretic Peptide Levels in Patients With Acute Dyspnea: Insights From the B-type Natriuretic Peptide for Acute Shortness of Breath Evaluation Study Michael Christ, Kirsten Laule-Kilian, Willibald Hochholzer, Theresia Klima, Tobias Breidthardt, Andre P. Perruchoud, Christian Mueller We examined whether B-type natriuretic peptide (BNP) levels allowed gender-specific risk stratification in 452 consecutive patients presenting with acute dyspnea to the emergency department. At 24 months, cumulative mortality was comparable in women and men. The area under the receiver-operating characteristic curve (AUC) for BNP to predict death was significantly higher in female (AUC: 0.80, 95% confidence interval [CI] 0.73 to 0.86) than in male patients (AUC: 0.64, 95% CI 0.57 to 0.71; p = 0.001 for the comparison of AUCwomenvs. AUCmen). Interaction analysis confirmed that BNP is a stronger predictor of death in women than in men (p = 0.008).
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2006.07.037