Left Ventricular Function in Long-Term Survivors of Childhood Lymphoma

• Published in: The American journal of cardiology 2014-08, Vol.114 (3), p.483-490
• Main Authors: Christiansen, Jon R., MD, Hamre, Hanne, MD, PhD, Massey, Richard, MSc, Dalen, Håvard, MD, PhD, Beitnes, Jan O., MD, PhD, Fosså, Sophie D., MD, PhD, Kiserud, Cecilie E., MD, PhD, Aakhus, Svend, MD, PhD
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age; Cardiology; Cardiovascular; Child; Drug therapy; Echocardiography; Female; Forecasting; Humans; Lymphoma - diagnostic imaging; Lymphoma - mortality; Lymphoma - physiopathology; Male; Medical research; Methods; Middle Aged; Norway - epidemiology; Radiation therapy; Registries; Retrospective Studies; Studies; Surveys and Questionnaires; Survival Rate - trends; Survivors - statistics & numerical data; Veins & arteries; Ventricular Function, Left - physiology; Young Adult
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2014.04.055

Survivors of childhood lymphoma (CL) have markedly increased risk of developing heart failure. Echocardiographic studies after cardiotoxic treatment have primarily demonstrated left ventricular (LV) systolic dysfunction. In the present study, we hypothesized that longer follow-up and a more comprehensive echocardiographic examination would reveal more cardiac abnormalities. We conducted a cross-sectional study with echocardiography 20.4 ± 8.6 years after diagnosis in 125 survivors of CL, grouped according to treatment methods, and compared with matched controls. Treatment included mediastinal radiotherapy (median 40.0 Gy) in 66 and anthracyclines (median dose 160 mg/m2 ) in 92 survivors of CL. Abnormal LV function, left-sided valve dysfunction, or both occurred in 62 patients (50%). Diastolic dysfunction occurred in 29%. Compared with control subjects, mitral annular early diastolic velocities (e′) were reduced in patients (septal e′ 0.09 ± 0.03 vs 0.12 ± 0.03 m/s, p