One-Pot Synthesis of 3-[(N-Alkylanilino)(aryl)methyl]indoles via a Transition Metal Assisted Three-Component Condensation at Room Temperature

• Published in: Journal of heterocyclic chemistry 2014-08, Vol.51 (S1), p.E140-E145
• Main Authors: Brahmachari, Goutam, Das, Suvankar
• Format: Article
• Language: English
• Subjects: Condensation; Temperature
• ISSN: 0022-152X; 1943-5193
• DOI: 10.1002/jhet.1909

A simple and highly efficient protocol for the one‐pot synthesis of a series of 3‐[(N‐alkylanilino)(aryl)methyl]indoles has been developed based on low‐cost and environmentally benign zirconium oxychloride octahydrate and copper chloride dihydrate catalysts via three‐component condensation between indoles, aromatic aldehydes, and N‐alkylanilines at room temperature under neat condition. Mild reaction conditions, operational simplicity, high atom‐economy, good yields in relatively shorter reaction times, use of low‐cost and eco‐friendly catalysts are some of the salient features of this protocol. A simple and highly efficient protocol for the one‐pot synthesis of a series of 3‐[(N‐alkylanilino)(aryl)methyl]indoles has been developed based on low‐cost and environmentally benign zirconium oxychloride octahydrate and copper chloride dihydrate catalysts via three‐component condensation between indoles, aromatic aldehydes, and N‐alkylanilines at room temperature under neat condition. Mild reaction conditions, operational simplicity, high atom‐economy, good yields in relatively shorter reaction times, and use of low‐cost and eco‐friendly catalysts are the key advantages of the present protocol.