Easily Accessible Auxiliary for Palladium-Catalyzed Intramolecular Amination of C(sp2)H and C(sp3)H Bonds at [delta]- and [epsi]-Positions

An easily synthesized and accessible N,O-bidentate auxiliary has been developed for selective CH activation under palladium catalysis. The novel auxiliary showed its first powerful application in CH functionalization of remote positions. Both C(sp2)H and C(sp3)H bonds at [delta]- and [epsi]-position...

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Bibliographic Details
Published in:Angewandte Chemie 2014-09, Vol.126 (37), p.10042
Main Authors: Wang, Chao, Chen, Changpeng, Zhang, Jingyu, Han, Jian, Wang, Qian, Guo, Kun, Liu, Pei, Guan, Mingyu, Yao, Yingming, Zhao, Yingsheng
Format: Article
Language:ger
Subjects:
Chemistry
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Summary:An easily synthesized and accessible N,O-bidentate auxiliary has been developed for selective CH activation under palladium catalysis. The novel auxiliary showed its first powerful application in CH functionalization of remote positions. Both C(sp2)H and C(sp3)H bonds at [delta]- and [epsi]-positions were effectively activated, thus giving tetrahydroquinolines, benzomorpholines, pyrrolidines, and indolines in moderate to excellent yields by palladium-catalyzed intramolecular CH amination.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201404854