Inhibition of demethylases by GSK-J1/J4/Kruidenier et al. reply

Here we show that the inhibitor is not specific for the H3K27me3/me2-demethylase subfamily in vitro and in tissue culture assays. Thus, the inhibitor cannot be used alone for drawing conclusions regarding the specific role of H3K27me3/me2-demethylase activity in biological processes or disease.

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Bibliographic Details
Published in:	Nature (London) 2014-10, Vol.514 (7520), p.E1
Main Authors:	Heinemann, Bo, Nielsen, Jesper Morten, Hudlebusch, Heidi Rye, Lees, Michael J, Larsen, Dorthe Vang, Boesen, Thomas, Labelle, Marc, Gerlach, Lars-Ole, Birk, Peter, Helin, Kristian, Kruidenier, Laurens, Chung, Chun-wa, Cheng, Zhongjun, Liddle, John, Che, KaHing, Joberty, Gerard, Bantscheff, Marcus, Bountra, Chas, Bridges, Angela, Diallo, Hawa, Eberhard, Dirk, Hutchinson, Sue, Jones, Emma, Katso, Roy, Leveridge, Melanie, Mander, Palwinder K, Mosley, Julie, Ramirez-Molina, Cesar, Rowland, Paul, Schofield, Christopher J, Sheppard, Robert J, Smith, Julia E, Swales, Catherine, Tanner, Robert, Thomas, Pamela, Tumber, Anthony, Drewes, Gerard, Oppermann, Udo, Patel, Dinshaw J, Lee, Kevin, Wilson, David M
Format:	Article
Language:	English
Subjects:	Amino acids Biomedical research Epigenetics Proteins
Online Access:	Get full text
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