Treatment with histamine‐type 2 receptor antagonists and omeprazole increase the risk of diarrhoea in neonatal foals treated in intensive care units

Reasons for performing study: The use of anti‐ulcer medication in the neonatal intensive care unit (ICU) is common due to the concern for development of catastrophic gastric ulcer disease. In man, however, the use of acid‐suppressive medication has been shown in some studies to be a substantial risk...

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Bibliographic Details
Published in:Equine veterinary journal 2012-02, Vol.44 (s41), p.80-86
Main Authors: FURR, M, COHEN, N. D, AXON, J. E, SANCHEZ, L. C, PANTALEON, L, HAGGETT, E, CAMPBELL, R, TENNENT‐BROWN, B
Format: Article
Language:English
Subjects:
acid-suppressive drugs
antagonists
bacteremia
Clostridium
Diarrhea
diarrhoea
drug therapy
Drugs
foals
horse
hospitals
Intensive care
neonate
neonates
risk factors
salmonellosis
stomach ulcers
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Summary:Reasons for performing study: The use of anti‐ulcer medication in the neonatal intensive care unit (ICU) is common due to the concern for development of catastrophic gastric ulcer disease. In man, however, the use of acid‐suppressive medication has been shown in some studies to be a substantial risk factor for the development of Clostridium difficile‐associated diarrhoea (CDAD), bacteraemia and neonatal sepsis. Objective: The purpose of the study reported herein is to evaluate the influence of anti‐ulcer medications on the development of diarrhoea in the neonatal foal. Hypothesis: The use of anti‐ulcer medication does not alter the incidence of diarrhoea in foals treated in an ICU. Methods: The records of 1710 foals from 6 different equine hospitals were examined and the use of anti‐ulcer drugs was recorded. The presence of in‐hospital acquired diarrhoea, CDAD, Clostridium perfringens‐associated diarrhoea, neonatal sepsis and salmonellosis were documented. In addition, the presence of gastric ulceration, duration of hospital stay and short‐term outcome were examined. Results: The use of anti‐ulcer medications increased the odds of in‐hospital diarrhoea by 2.0 (95% CI 1.4–2.9; P
ISSN:0425-1644
2042-3306
DOI:10.1111/j.2042-3306.2011.00499.x