Presumptive nonthyroidal illness syndrome in critically ill foals

Reasons for performing the study: Hypothalamic‐pituitary‐thyroid (HPT) axis dysfunction is associated with morbidity and mortality in critically ill people. To date, investigations of HPT axis in critically ill foals are limited. Objectives: To document the occurrence of low thyroid hormone concentr...

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Bibliographic Details
Published in:Equine veterinary journal 2012-02, Vol.44 (s41), p.43-47
Main Authors: HIMLER, M, HURCOMBE, S. D. A, GRIFFIN, A, BARSNICK, R. J, RATHGEBER, R. A, MACGILLIVRAY, K. C, TORIBIO, R. E
Format: Article
Language:English
Subjects:
disease severity
euthyroid sick syndrome
foal
foals
Hormones
Illnesses
morbidity
mortality
neonates
people
prematurity
radioimmunoassays
Sepsis
sepsis (infection)
therapeutics
thyroid
thyroxine
triiodothyronine
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Summary:Reasons for performing the study: Hypothalamic‐pituitary‐thyroid (HPT) axis dysfunction is associated with morbidity and mortality in critically ill people. To date, investigations of HPT axis in critically ill foals are limited. Objectives: To document the occurrence of low thyroid hormone concentrations (presumptive nonthyroidal illness syndrome; NTIS) in critically ill newborn foals and investigate whether NTIS is associated with severity of disease and outcome. Hypothesis: NTIS occurs frequently in foals with sepsis and is associated with sepsis score and outcome. Reverse T3 (rT3) concentrations will be increased in septic foals and highest in nonsurvivors. Methods: Thyroid hormones (total and free thyroxine [TT4 and fT4], total and free tri‐iodothyronine [TT3 and fT3], reverse T3 [rT3]) were prospectively measured in healthy, sick nonseptic and septic foals. Clinical and laboratory information was retrieved from the medical records. Hormones were measured by validated radioimmunoassays. Results: Concentrations of all thyroid hormones except rT3 (P = 0.69) were decreased in septic and sick nonseptic foals (P
ISSN:0425-1644
2042-3306
DOI:10.1111/j.2042-3306.2011.00480.x