In vitro assessment of halobacterial gas vesicles as aChlamydiavaccine display and delivery system

Highlights * Gas vesicles (Gv) displayChlamydiaproteins as part of their membrane structures. * Recombinant gas vesicles (r-Gv) are readily recognized by human immune sera. * Gv engage TLRs and stimulate proinflammatory cytokines in a peptide-specific manner. * Temporal degradation of Gv in vitro, c...

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Published in:Vaccine 2012-09, Vol.30 (41), p.5942
Main Authors: Childs, Tawanna S, Webley, Wilmore C
Format: Article
Language:English
Subjects:
Antibiotics
Antigens
Cloning
Cytokines
Deoxyribonucleic acid
DNA
Gases
Infections
Laboratories
Peptides
Plasmids
Proteins
Sexually transmitted diseases
STD
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Webley, Wilmore C
description Highlights * Gas vesicles (Gv) displayChlamydiaproteins as part of their membrane structures. * Recombinant gas vesicles (r-Gv) are readily recognized by human immune sera. * Gv engage TLRs and stimulate proinflammatory cytokines in a peptide-specific manner. * Temporal degradation of Gv in vitro, culminates in antigen display at cell surface. * R-Gv promise to be an ideal multisubunit vaccine display/delivery platform.
doi_str_mv 10.1016/j.vaccine.2012.07.038
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subjects Antibiotics
Antigens
Cloning
Cytokines
Deoxyribonucleic acid
DNA
Gases
Infections
Laboratories
Peptides
Plasmids
Proteins
Sexually transmitted diseases
STD
title In vitro assessment of halobacterial gas vesicles as aChlamydiavaccine display and delivery system
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