Impact of Weight Loss on Ankle-Brachial Index and Interartery Blood Pressures

To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis. The Action for Health in Diabetes randomized clinical trial compared intensive lifestyle intervention (ILI) for weight loss to a control condition of diabetes support and education (DSE) in overweight...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2014-04, Vol.22 (4), p.1032
Main Authors: Espeland, Mark A, Lewis, Cora E, Bahnson, Judy, Knowler, William C, Regensteiner, Judith G, Gaussoin, Sarah A, Beavers, Daniel, Johnson, Karen C
Format: Article
Language:English
Subjects:
Ankle
Atherosclerosis
Body mass index
Clinical trials
Diabetes
Family medical history
Heart attacks
Nutrition research
Weight control
Writing
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Summary:To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis. The Action for Health in Diabetes randomized clinical trial compared intensive lifestyle intervention (ILI) for weight loss to a control condition of diabetes support and education (DSE) in overweight or obese adults with type 2 diabetes. Annual ankle and brachial blood pressures over four years were used to compute ankle-brachial indices (ABIs) and to assess interartery blood pressure differences in 5018 participants. ILI, compared to DSE, produced 7.8% (Year 1) to 3.6% (Year 4) greater weight losses. These did not affect prevalence of low (1.40) ABI (7.52% in DSE versus 7.59% in ILI: P = 0.90), but produced smaller mean (SE) maximum interartery systolic blood pressure differences among ankle sites [19.7 (0.2) mmHg for ILI versus 20.6 (0.2) mmHg for DSE (P < 0.001)] and between arms [5.8 (0.1) mmHg for ILI versus 6.1 (0.1) mmHg for DSE (P = 0.01)]. Four years of intensive behavioral weight loss intervention did not significantly alter prevalence of abnormal ABI, however, it did reduce differences in systolic blood pressures among arterial sites.
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.20658;0001981235