Stereocontrolled Synthesis of the C1-C10 Fragments of MonensinB and Laidlomycin

An efficient synthetic route to the C1-C10 fragments of laidlomycin and monensin B has been developed toward their total synthesis. The asymmetric carbons have been elaborated by a syn-aldol reaction using the oxazolidinone chiral auxiliary for C6 and C7, an anti-aldol reaction for C3 and C4, the Ti...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2015-06, Vol.4 (6), p.567
Main Authors: Kang, Sungkyoung, Lee, Wonchul, Jung, Byunghyuck, Lee, Hee-Seung, Kang, Sung Ho
Format: Article
Language:English
Subjects:
Organic chemistry
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Summary:An efficient synthetic route to the C1-C10 fragments of laidlomycin and monensin B has been developed toward their total synthesis. The asymmetric carbons have been elaborated by a syn-aldol reaction using the oxazolidinone chiral auxiliary for C6 and C7, an anti-aldol reaction for C3 and C4, the Tishchenko-Evans reaction for C5, and a chiral building block for C2.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.201500078